ABSTRACT
OBJECTIVE@#To determine the effectiveness and safety of essential oil from Citrus aurantium on anxiety in patients undergoing coronary angiography.@*METHODS@#A single-blind, randomized controlled trial was conducted in 80 patients experiencing coronary angiography in Imam Ali Hospital in Kermanshah, Iran from April to November in 2016. All patients were randomly divided into intervention and control groups by a random number table, 40 cases in each group. The patients in the intervention group inhaled Citrus aurantium essential oil for 15-20 min about 60 min before angiography. Following the same procedure, distilled water was used instead of Citrus aurantium in the control group. Spielbergers State-Trait Anxiety Inventory (STAI) was filled in and vital signs including systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory and pulse rate were recorded before and 20 min after the intervention. Adverse reactions after intervention were observed.@*RESULTS@#In the intervention group, the mean scores of STAI, SBP, DBP, respiratory and pulse rate were 53.30 ± 10.13, 134.82 ± 11.75 mm Hg, 84.49 ± 6.99 mm Hg, 17.87 ± 1.73 times/min, and 76.48 ± 12.55 beats/min at baseline and significantly decreased to 42.37 ± 10.15, 124.49 ± 10.48 mm Hg, 79.23 ± 6.62 mm Hg, 14.54 ± 1.43 times/min, and 70.03 ± 13.66 beats/min respectively 20 min after intervention (all P0.05). All subjects reported no adverse reactions.@*CONCLUSION@#Inhalation of the essential oil from Citrus aurantium was effective in reducing anxiety and stress levels in patients undergoing coronary angiography.@*TRIAL REGISTRATION@#IRCT2016040816797N2 (retrospectively registered on 21 April 2016, https://en.irct.ir/trial/15600 ).
ABSTRACT
Brucellosis is an old, infectious and common zoonosis whose causative agents are Gramnegative bacteria from the Brucella genus. Brucellosis is transmitted through direct contact with infected animals or using unpasteurized dairy products of goats, pigs, camels, sheep, buffalo and cows. Brucellosis is still the most common zoonosis in the world, with most of cases occurring in developing countries. Today, an approach to traditional medicine and medicinal plants, especially with regards to the repeated recommendations of the World Health Organization, is a necessity. One-third of chemical drugs are produced by using plants and there is a high potential to produce more drugs from plants. Medicinal plants are helpful in the management of various conditions, especially bacterial diseases. Although there is not enough scientific evidence regarding the clinical effectiveness of herbal drugs for the treatment of brucellosis, there is strong evidence on the antimicrobial effects of herbal drugs to prevent infection. Therefore, this article seeks to describe the antibacterial effects of some plant-derived essential oils or extracts, so that they can serve as promising choices to develop new anti-Brucella medications, as suitable alternatives to conventional antibiotics for brucellosis, as much as possible, taking into account the benefits of these herbal drugs.
ABSTRACT
Background: Enzymes are well known as sensitive catalysts in the laboratory and industrial scale. To improve their properties and for using their significant potential in various reactions as a useful catalyst the stability of enzymes can often require improvement. Enzymes Immobilization on solid supports such as epoxy- functionalized ferric silica nanocomposite can be effective way to improve their characteristics
Methods: In this study silica coated magnetite nanoparticles were Functionalized with GPTSM as a linker, then immobilization reaction performed by using various amounts of lipase B from Candida Antarctica [CALB], for the next step immobilization effects on thermal stability and optimum pH were investigated in comparison with free CALB
Results: Results illustrated enzyme was successfully immobilized on nano particles and immobilized derivative retains 100% of its activity by 55 degree C while free CALB loss its activity at the same condition
Conclusion: Immobilization of CALB on Fe3O4@SiO2 particles resulted in significant improvements in its characteristics such as thermal stability and methanol tolerance compared to the free CALB
ABSTRACT
Preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin [Hp] phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical features in this disease. This cross-sectional analytic descriptive study has been carried out in two groups of 120 women, 60 with preterm and 60 with term labor. Patients were selected with previously diagnosed by gynecologist with preterm birth in the labor during the study period. After performing diagnostic tests, the frequency of each haptoglobin phenotype in the two groups was analyzed using the Chi-square test [X2] test and SPSS software. The maximum serum haptoglobin phenotype frequency in patients with Hp2-2, was 43 [71.7%] whereas in healthy individuals, 35 [58.3%]. No, statistically significant differences between the two groups were found [p=0.310]. But based on some patients clinical features such as their history of preterm delivery, previous history of recurrent abortions and history of preterm delivery in their family, significant association was found with Hp2-2 compared with healthy control [p<0.003]. This study showed that Hp2-2 phenotypes levels in the case group was higher than in control but the factors influencing the presence or absence of preterm labor is clinically various
ABSTRACT
Preterm birth means the birth before thirty seven week of pregnancy that causes a lot of complications for the baby. Variety factors are suggested to be involved in disease. In this study, we decided to evaluate haptoglobin [Hp] phenotypes association with clinical features of patients suffered from premature delivery to understand better the possible correlation of genetic and clinical features in this disease. This cross sectional analytic descriptive study has been carried out in two groups of 120 women, 60 with preterm and 60 with term labor. Patients were selected with previously diagnosed by a gynecologist with preterm birth in hospital during the study period. After performing diagnostic tests, the frequency of each haptoglobin phenotype in the two groups was analyzed using the X2 test and SPSS software. The maximum serum haptoglobin phenotype frequency in patients with Hp2-2, was 43 [71.7%] whereas in healthy individuals, 35 [58.3%]. No statistically significant differences between the two groups was found [P=0.310]. But based on some patients clinical features such as their history of preterm delivery, previous history of recurrent abortions and history of preterm delivery in their family, significant association was found with Hp2-2 compared with healthy control [P<0.003]. This study showed that Hp2-2 phenotypes levels in the case group was higher than in control but the factors influencing the presence or absence of preterm labor is clinically various.
Subject(s)
Humans , Female , Obstetric Labor, Premature , Phenotype , Pregnancy , Cross-Sectional Studies , Electrophoresis, Polyacrylamide GelABSTRACT
Laparoscopic cholecystectomy is associated with shorter hospital stay and less pain in comparison to open surgery. The aim of this study was to evaluate the effect of intraperitoneal hydrocortisone on pain relief following laparoscopic cholecystectomy. Sixty two patients were enrolled in a double-blind, randomized clinical trial. Patients randomly received intraperitoneal instillation of either 250 ml normal saline [n=31] or 100 mg hydrocortisone in 250 ml normal saline [n=31] before insufflation of CO[2] into the peritoneum. Abdominal and shoulder pain were evaluated using VAS after surgery and at 6, 12, and 24 hours postoperatively. The patients were also followed for postoperative analgesic requirements, nausea and vomiting, and return of bowel function. Sixty patients completed the study. Patients in the hydrocortisone group had significantly lower abdominal and shoulder pain scores [10.95 vs 12.95; P<0.01]. The patients were similar regarding analgesic requirements in the recovery room. However, those in the hydrocortisone group required less meperidine than the saline group [151.66 [ +/- 49.9] mg vs 61.66 [ +/- 38.69] mg; P=0.00]. The patients were similar with respect to return of bowel function, nausea and vomiting. No adverse reaction was observed in either group. Intraperitoneal administration of hydrocortisone can significantly decrease pain and analgesic requirements after laparoscopic cholecystectomy with no adverse effects
Subject(s)
Humans , Female , Male , Hydrocortisone , Injections, Intraperitoneal , Pain, Postoperative/therapy , Hydrocortisone/administration & dosageABSTRACT
Allergic rhinitis [AR] is an allergic disorder of the nasal tissue that underlies diseases such as sinusitis, otits and asthma. Different predisposing factors including immunological and non-immunological factors contribute to the disease pathogenesis. To investigate association of haptoglobin [Hp] phenotypes [Hp1-1, 2-1 and 2-2] with serum immunoglobulins A and E levels in patients suffering from AR in comparison with healthy individuals. Two hundred and forty patients and 240 healthy individual entered in this case-control study. Serum levels of IgE and IgA were measured and haptoglobulin phenotypes were determined by electrophoresis. The results were evaluated by chi[2] statistical test using SPSS software. Serum electrophoresis showed that the distribution of haptoglobin phenotypes of Hp1-1, Hp2-1 and Hp2-2 among 240 patients were 11.3%, 37.9% and 50.8%, respectively. The distribution of different haptoglobin phenotypes in healthy controls were 88.7%, 36.6% and 54.7%, respectively. However, the difference between patients and controls was not statistically significant [p=0.136]. The mean of IgE level was significantly higher in patients than controls in association with all three phenotypes [p<0.001]. Mean of IgA serum level was also significantly different between case and control groups for Hp1-1 [p<0.048] and Hp2-2 phenotypes [p<0.027]. We conclude that there is an association of all three haptoglobin phenotypes with IgE level. Hp1-1 and Hp2-2 phenotypes showed association with IgA in allergic rhinitis, as well. However, we cannot solely attribute these associations to the pathogenesis of allergic rhinitis
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The objective of this study is to describe the proportion of patients with chronic cough and negative smear microscopy appropriately diagnosed as tuberculosis [TB] and to identify clinical features that could be used in developing a diagnostic scoring system for smear-negative patients. Records of patients with chronic cough and > 3 negative sputum smears for acid fast bacilli who attended a reference University hospital in south-eastern Iran and screened by culture were retrospectively reviewed. We compared confirmed smear-negative pulmonary TB [PTB; culture-positive] and unconfirmed smear-negative patients [culture-negative] to describe the appropriateness of treatment and their characteristics. Features independently predictive of smear-negative PTB [SNPTB] were entered into a logistic regression to create a diagnostic rule. This study enrolled 350 patients, of which 52 [14.8%] were culture-positive and 298 [85.2%] culture-negative. Of these, 38 out of 52 [sensitivity 73%] confirmed SNPTB were diagnosed as TB and 283 out of 298 [specificity 95%] unconfirmed sputum-negative patients were diagnosed as non-PTB. Variables associated with confirmed SNPTB were the presence of night sweats, family history of TB, typical chest radiography, erythrocyte sedimentation rate > 45 mm and white blood cell count < 11000/mL. The score constructed with these variables had a sensitivity of 94% and specificity of 74% with an area under the curve of 0.90. The clinical differences between SNPTB and control patients could be used to develop a clinical scoring system to identify patients with SNPTB
Subject(s)
Humans , Male , Female , Tuberculosis, Pulmonary , Sputum , Chronic Disease , Retrospective StudiesABSTRACT
Acute lymphoblastic leukemia is a lymphoid malignancy, resulting from autonomous proliferation of monoclonal abnormal stem cell. The aim of this study was to evaluate the response rate and prognostic factor of adult patients suffering from acute lymphoblastic leukemia, who were treated with chemotherapy in south east of Iran and demographic methods were used for this study. This study was conducted in Ali Ebne Abitaleb Hospital in south east of Iran [Zahedan] from 2003-2010. All adult patients with acute lymphoblastic leukemia in hematology ward received Vincristin, Daunorubicin, Cyclophosphamide, Prednisolone and high dose Methotrexate for induction therapy. All patients' information was recorded and multivariate analysis and survival studies were performed by using Kaplan-Meier statistics. Sixty six adult patients entered. Mean age of them was 33 years old [16-68], that 53 [80.3%] cases were male and 13 cases were female. Fifty one [77.3%] cases experienced complete remission and 15 [22.7%] cases had no remission state. In the following year 53%[33] was alive with complete remission and 47%[31] were dead. Median survival was 13 months. In the end of study 30 cases were in complete remission and alive and 36 [54.5%] were dead. Our results were comparable with other studies and minimally better than those studies
Subject(s)
Humans , Male , Female , Treatment Outcome , Antineoplastic Agents , Vincristine , Daunorubicin , Cyclophosphamide , Prednisolone , Methotrexate , Stem CellsABSTRACT
We present a 56-year-old female with end stage renal disease [ESRD]. As the patient had no vascular access for hemodialysis, the catheter was inserted in the right subclavian vein without an imaging guide. The woman experienced sudden chest pain and hypotension. Imaging showed a malposition of the catheter in the subclavian artery instead of the subclavian vein with dissection of the thoracic and abdominal aorta. This is a rare complication of subclavian vein catheterization for hemodialysis. We discuss this patient because she is the first in the international bibliography. This case report shows that for patients with poor venous access, catheter placement under angiographic control may be helpful